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Article

Personalized Therapeutics for KATP-Dependent Pathologies.

Annual review of pharmacology and toxicology - 20 Jan 2023

Nichols Colin G

Abstract excerpt

Ubiquitously expressed throughout the body, ATP-sensitive potassium (KATP) channels couple cellular metabolism to electrical activity in multiple tissues; their unique assembly as four Kir6 pore-forming subunits and four sulfonylurea receptor (SUR) subunits has resulted in a large armory of selective channel opener and inhibitor drugs. The spectrum of monogenic pathologies that result from gain- or...

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Identifiers

PMID: 36170658
DOI: 10.1146/annurev-pharmtox-051921-123023
PMCID: PMC9868118

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