Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human KATP channelopathies: diseases of metabolic homeostasis

23 Dec 2009

Abstract excerpt

Assembly of an inward rectifier K+ channel pore (Kir6.1/Kir6.2) and an adenosine triphosphate (ATP)-binding regulatory subunit (SUR1/SUR2A/SUR2B) forms ATP-sensitive K+ (KATP) channel heteromultimers, widely distributed in metabolically active tissues throughout the body. KATP channels are metabolism-gated biosensors functioning as molecular rheostats that adjust membrane potential-dependent functions to match...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Ischemia and Reperfusion
Share to Ion channel regulation and function

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 20033705
DOI: 10.1007/s00424-009-0771-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human KATP channelopathies: diseases of metabolic homeostasisPMID 20033705Read ↗

ATP-sensitive potassium channels in health and disease.Semantic proximity Read ↗

Cardiac KATP channels in health and disease.Semantic proximity Read ↗

Personalized Therapeutics for KATP-Dependent Pathologies.Semantic proximity Read ↗

Ion Transporters, Channelopathies, and Glucose DisordersSemantic proximity Read ↗

Molecular biology of K(ATP) channels and implications for health and disease.Semantic proximity Read ↗

The Pharmacology of ATP-Sensitive K+ Channels (KATP).Semantic proximity Read ↗

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating.Semantic proximity Read ↗

ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.Semantic proximity Read ↗

Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.Semantic proximity Read ↗

New insights into KATP channel gene mutations and neonatal diabetes mellitus.Semantic proximity Read ↗

The channelopathies: novel insights into molecular and genetic mechanisms of human disease.Semantic proximity Read ↗

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.