Article
Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Jan 2009
Aittoniemi Jussi, Fotinou Constantina, Craig Tim J, de Wet Heidi, Proks Peter, Ashcroft Frances M
Abstract excerpt
SUR1 is an ATP-binding cassette (ABC) transporter with a novel function. In contrast to other ABC proteins, it serves as the regulatory subunit of an ion channel. The ATP-sensitive (KATP) channel is an octameric complex of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits, and it links cell metabolism to electrical activity in many cell types. ATPase activity at the nucleotide-binding domains of...
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