Article

Absolute copy number fitting from shallow whole genome sequencing data

2021-07-20

Abstract excerpt

Low-coverage or shallow whole genome sequencing (sWGS) approaches can efficiently detect somatic copy number aberrations (SCNAs) at low cost. This is clinically important for many cancers, in particular cancers with severe chromosomal instability (CIN) that frequently lack actionable point mutations and are characterised by poor disease outcome. Absolute copy number (ACN), measured in DNA copies per cancer cell, i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd47c3ec-357f-5261-80a7-32710b7caf92
DOI: 10.1101/2021.07.19.452658

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Absolute copy number fitting from shallow whole genome sequencing dataDOI 10.1101/2021.07.19.452658Read

Alleloscope: Integrative single cell analysis of allele-specific copy number alterations and chromatin accessibility in cancerSemantic proximity Read

Methods for Copy Number Aberration Detection from Single-cell DNA Sequencing DataSemantic proximity Read

Alleloscope: Integrative single cell analysis of allele-specific copy number alterations and chromatin accessibility in cancerSemantic proximity Read

Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer.Semantic proximity Read

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications.Semantic proximity Read

Improved allele-specific single-cell copy number estimation in low-coverage DNA-sequencing.Semantic proximity Read

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolutionSemantic proximity Read

TeaCNV: decoding tumor somatic absolute copy number and clonal architecture from single cell chromatin accessibility dataSemantic proximity Read

Integrative pipeline for profiling DNA copy number and inferring tumor phylogenySemantic proximity Read

Signatures of copy number alterations in human cancer.Semantic proximity Read

A single-sample method for normalizing and combining full-resolution copy numbers from multiple platforms, labs and analysis methods.Semantic proximity Read

Integrative pipeline for profiling DNA copy number and inferring tumor phylogeny.Semantic proximity Read