Article

<i>SAMHD1</i> Knockout iPSC model enables high lenti-viral transduction in myeloid cell types

2025-02-05

Abstract excerpt

Recent advances in functional genomics tools have ushered in a new era of genetic editing to identify molecular pathways relevant to developmental and disease biology. However, limited model systems are available that adequately mimic cell states and phenotypes associated with human disease pathways. Here, we quantitatively analyzed the founder population bottleneck effect and demonstrated how the population chang...

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Literature Corpus work: bd3c525d-b173-5b73-ae65-d204dacfa140
DOI: 10.1101/2025.02.04.636295

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