Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.

doi:10.1161/CIRCRESAHA.117.305860

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Article

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.

Circulation research - 19 Jun 2015

Zhang Hanrui, Xue Chenyi, Shah Rhia, Bermingham Kate, Hinkle Christine C, Li Wenjun, Rodrigues Amrith, Tabita-Martinez Jennifer, Millar John S, Cuchel Marina, Pashos Evanthia E, Liu Ying, Yan Ruilan, Yang Wenli, Gosai Sager J, VanDorn Daniel, Chou Stella T, Gregory Brian D, Morrisey Edward E, Li Mingyao, Rader Daniel J, Reilly Muredach P

Abstract excerpt

RATIONALE: An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases. OBJECTIVE: To perform integrated functional and transcriptome analyses of human induced pluripotent stem cell-derived macrophages (IPSDMs) and their isogenic human peripheral blood mononuclear cell-derived macrophage (HMDM) counterparts and assess the...

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PMID: 25904599
DOI: 10.1161/CIRCRESAHA.117.305860
PMCID: PMC4565503

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