Article

Gene editing in “cell villages” enables exploring disease-relevant mutations in many genetic backgrounds

2025-11-09

Abstract excerpt

Understanding how individual genetic backgrounds shape the effects of disease-associated mutations is central to elucidating the biology of complex psychiatric disorders. We developed a scalable ‘village editing’ strategy that enables simultaneous genome editing across multiple induced pluripotent stem cell (iPSC) lines, allowing systematic assessment of how polygenic context modulates the impact of specific mutat...

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Identifiers and source

Literature Corpus work: 85404e80-476c-5652-bfbc-addf5c5b9912
DOI: 10.1101/2025.11.08.687374

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