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Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

28 Jun 2016

Abstract excerpt

SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-mediated genome editing coupled to a cell selection step by FACS to identify regulators of SQSTM1. Through systematic comparison of pooled libraries, we show that...

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PMID: 27351204
DOI: 10.7554/elife.17290

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