Article

DNA binding and lesion recognition by the bacterial interstrand DNA crosslink glycosylase AlkX

2025-12-13

Abstract excerpt

Interstrand DNA crosslinks (ICLs) are a highly toxic form of DNA damage. ICL repair in both eukaryotes and bacteria involves unhooking of the two strands by specialized DNA glycosylases. We recently established that the human pathogen Acinetobacter baumannii contains an ICL glycosylase (AlkX) that facilitates pathogenesis and protects the bacteria from DNA damage and acid stress. However, the physical basis for g...

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Literature Corpus work: bd0c7de3-dbed-5df3-8337-a553bd361c99
DOI: 10.64898/2025.12.11.693820

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