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Article

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.

Nature - 12 Sept 2002

Trewick Sarah C, Henshaw Timothy F, Hausinger Robert P, Lindahl Tomas, Sedgwick Barbara

Abstract excerpt

Methylating agents generate cytotoxic and mutagenic DNA damage. Cells use 3-methyladenine-DNA glycosylases to excise some methylated bases from DNA, and suicidal O(6)-methylguanine-DNA methyltransferases to transfer alkyl groups from other lesions onto a cysteine residue. Here we report that the highly conserved AlkB protein repairs DNA alkylation damage by means of an unprecedented mechanism. AlkB has no...

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Identifiers

PMID: 12226667
DOI: 10.1038/nature00908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.PMID 12226667Read ↗

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