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Article

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.

Nucleic acids research - 1 Jan 2004

Mishina Yukiko, Lee Chih-Hui J, He Chuan

Abstract excerpt

The Escherichia coli AlkB protein was recently found to repair cytotoxic DNA lesions 1-methyladenine and 3-methylcytosine by using a novel iron-catalyzed oxidative demethylation mechanism. Three human homologs, ABH1, ABH2 and ABH3, have been identified, and two of them, ABH2 and ABH3, were shown to have similar repair activities to E.coli AlkB. However, ABH1 did not show any repair activity. It was suggested that...

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PMID: 15004242
DOI: 10.1093/nar/gkh319
PMCID: PMC390304

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