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Article

Structure of a DNA glycosylase that unhooks interstrand cross-links.

Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2017

Mullins Elwood A, Warren Garrett M, Bradley Noah P, Eichman Brandt F

Abstract excerpt

DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism. These enzymes have been known only to initiate base excision repair of small adducts by extrusion from the DNA helix. However, recent reports have described both vertebrate and microbial DNA glycosylases capable of unhooking highly toxic interstrand...

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Identifiers

PMID: 28396405
DOI: 10.1073/pnas.1703066114
PMCID: PMC5410837

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