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Article

Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.

The Journal of biological chemistry - 10 Jul 2015

Wang Lan, Lee Seung-Joo, Verdine Gregory L

Abstract excerpt

The highly mutagenic A:oxoG (8-oxoguanine) base pair in DNA most frequently arises by aberrant replication of the primary oxidative lesion C:oxoG. This lesion is particularly insidious because neither of its constituent nucleobases faithfully transmit genetic information from the original C:G base pair. Repair of A:oxoG is initiated by adenine DNA glycosylase, which catalyzes hydrolytic cleavage of the aberrant A...

Topics

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Catalytic Domain
Crystallography, X-Ray
DNA Damage
DNA Glycosylases
Geobacillus stearothermophilus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Substrate Specificity

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Open in PubMed Open full text

Identifiers

PMID: 25995449
DOI: 10.1074/jbc.M115.657866
PMCID: PMC4498048

Genes

MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.PMID 25995449Read ↗

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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNASemantic proximity Read ↗

Distinctive Formation of a DNA-Protein Cross-Link during the Repair of DNA Oxidative Damage: Insights into Human Disease from MD Simulations and QM/MM Calculations.Semantic proximity Read ↗

Intact MutY and its catalytic domain differentially contact with A/8-oxoG-containing DNA.Semantic proximity Read ↗

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Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.Semantic proximity Read ↗

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