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Article

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.

PloS one - 1 Jan 2014

Zdżalik Daria, Vågbø Cathrine B, Kirpekar Finn, Davydova Erna, Puścian Alicja, Maciejewska Agnieszka M, Krokan Hans E, Klungland Arne, Tudek Barbara, van den Born Erwin, Falnes Pål Ø

Abstract excerpt

The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno adducts on the nucleobases. Humans have nine different ALKBH proteins, ALKBH1-8 and FTO. Mammalian and plant ALKBH8 are tRNA hydroxylases targeting 5-methoxycarbonylmethyl-modified uridine...

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Source

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Identifiers

PMID: 24914785
DOI: 10.1371/journal.pone.0098729
PMCID: PMC4051686

Genes

ALKBH8
ALKBH1
FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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