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Article

Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation.

Brain pathology (Zurich, Switzerland) - 1 Nov 2018

Schlüter Agatha, Sandoval Juan, Fourcade Stéphane, Díaz-Lagares Angel, Ruiz Montserrat, Casaccia Patrizia, Esteller Manel, Pujol Aurora

Abstract excerpt

Epigenomic changes may either cause disease or modulate its expressivity, adding a layer of complexity to mendelian diseases. X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic condition exhibiting discordant phenotypes, ranging from a childhood cerebral inflammatory demyelination (cALD) to an adult-onset mild axonopathy in spinal cords (AMN). The AMN form may occur with superimposed inflammatory...

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Share to ATP Binding Cassette Transporter, Subfamily D, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29476661
DOI: 10.1111/bpa.12595
PMCID: PMC6857458

Genes

AMN
ABCD1
CD59
CNP
COL9A3
ID4
IFITM1
MBP
MOG
PLP1
UNC45A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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