Article

Polymorphisms in human APOBEC3H differentially regulate ubiquitination and antiviral activity

2020-02-09

Abstract excerpt

The APOBEC3 family of cytidine deaminases are an important part of the host innate immune defense against endogenous retroelements and retroviruses like human immunodeficiency virus (HIV). APOBEC3H ( A3H ) is the most polymorphic of the human APOBEC3 genes, with four major haplotypes circulating in the population. Haplotype II is the only antivirally-active variant of A3H , while the majority of the population...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd0397fb-0d55-5bed-b9f9-99a5b88aef1a
DOI: 10.1101/2020.02.07.939439

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in human APOBEC3H differentially regulate ubiquitination and antiviral activityDOI 10.1101/2020.02.07.939439Read

Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral ActivitySemantic proximity Read

Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity.Semantic proximity Read

Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities.Semantic proximity Read

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integritySemantic proximity Read

Human APOBEC3 Variations and Viral InfectionSemantic proximity Read

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.Semantic proximity Read

Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.Semantic proximity Read

Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional ActivitiesSemantic proximity Read

Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 ActivitySemantic proximity Read

Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.Semantic proximity Read

Recurrent Loss of APOBEC3H Activity during Primate EvolutionSemantic proximity Read

A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity.Semantic proximity Read