Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity.

Journal of virology - 1 Aug 2011

Li Melody M H, Emerman Michael

Abstract excerpt

The APOBEC3 family of cytidine deaminases is part of the innate host defense targeted toward retroviruses and retroelements. APOBEC3H is the most distantly related member of the family and carries functional polymorphisms in current human populations. Haplotype II of APOBEC3H, which is more commonly found in individuals of African descent, encodes a protein with the highest antiviral activity in cells, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Aminohydrolases
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine Deaminase

Share to Diffusion

Share to HeLa Cells

Share to Protein Stability

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 21653666
DOI: 10.1128/JVI.00624-11
PMCID: PMC3147987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity.PMID 21653666Read ↗

Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.Semantic proximity Read ↗

Polymorphisms in human APOBEC3H differentially regulate ubiquitination and antiviral activitySemantic proximity Read ↗

Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral ActivitySemantic proximity Read ↗

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for RestrictionSemantic proximity Read ↗

Nuclear Exclusion of the HIV-1 Host Defense Factor APOBEC3G Requires a Novel Cytoplasmic Retention Signal and Is Not Dependent on RNA BindingSemantic proximity Read ↗

Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate SpeciesSemantic proximity Read ↗

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.Semantic proximity Read ↗

Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities.Semantic proximity Read ↗

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 proteaseSemantic proximity Read ↗

Polymorphisms and splice variants influence the antiretroviral activity of human APOBEC3H.Semantic proximity Read ↗

The mechanisms regulating the subcellular localization of AID.Semantic proximity Read ↗

Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.