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Article

Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity

30 Mar 2020

Abstract excerpt

The APOBEC3 family of cytidine deaminases are an important part of the host innate immune defense against endogenous retroelements and retroviruses like Human Immunodeficiency Virus (HIV). APOBEC3H (A3H) is the most polymorphic of the human APOBEC3 genes, with four major haplotypes circulating in the population. Haplotype II is the only antivirally-active variant of A3H, while the majority of the population...

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PMID: 32235597
DOI: 10.3390/v12040378

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