Article

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

2022-06-16

Abstract excerpt

Genetic determinants of susceptibility to Mycobacterium tuberculosis ( Mtb ) are poorly understood but could provide insights into critical pathways involved in infection, informing host-directed therapies and enabling risk stratification at individual and population levels. Through a genome-wide forward genetic screen, we identify the Toll-like Receptor 8 (TLR8), as a key regulator of intracellular killing of...

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Literature Corpus work: 1d497c36-b214-55fa-91ac-dbdff80c02ee
DOI: 10.1101/2022.06.14.496072

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