Article

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

2022-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Necrosis of macrophages in the tuberculous granuloma represents a major pathogenic event in tuberculosis. Through a zebrafish forward genetic screen, we identified the mTOR kinase, a master regulator of metabolism, as an early host resistance factor in tuberculosis. We found that mTOR complex 1 protects macrophages from mycobacterium-induced death by enabling infection-induced increases in mitoc...

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Literature Corpus work: e431d27b-c248-51f0-8266-b168ae18ab40
DOI: 10.1101/2022.01.30.478369

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