Article

Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring

2024-06-11

Abstract excerpt

The natural diversity of Mycobacterium tuberculosis is gaining relevance in dictating the outcome of tuberculosis (TB). We previously revealed a link between TB severity and M. tuberculosis -driven evasion of the macrophage cytosolic surveillance systems, with isolates from severe TB cases reducing inflammasome activation and interleukin (IL)-1β production by infected cells. IL-1β production and inflammasome act...

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Literature Corpus work: 5fe5ff6d-f04d-5503-814c-f41801ba3f67
DOI: 10.1101/2024.06.10.598180

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