Article

Structure and engineering of Brevibacillus laterosporus Cas9

2024-01-08

Abstract excerpt

<title>Abstract</title> <p>The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets complementary to an RNA guide, and is widely used as a powerful genome-editing tool. Here, we report the crystal structure of <italic>Brevibacillus laterosporus</italic> Cas9 (BlCas9), a compact Cas9 comparable to versatile <italic>Staphylococcus aureus</italic> Cas9 (SaCas9), in complex with a guide RNA and its ta...

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Literature Corpus work: bca8dfac-0162-5a57-8337-eec76ae6dbe5
DOI: 10.21203/rs.3.rs-3717633/v1

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