Article

Rational Design of Enhanced Nme2Cas9 and Nme2 <sup>Smu</sup> Cas9 Nucleases and Base Editors

2024-10-30

Abstract excerpt

CRISPR-Cas genome editing tools enable precise, RNA-guided modification of genomes within living cells. The most clinically advanced genome editors are Cas9 nucleases, but many nuclease technologies provide only limited control over genome editing outcomes. Adenine base editors (ABEs) and cytosine base editors (CBEs) enable precise and efficient nucleotide conversions of A:T-to-G:C and C:G-to-T:A base pairs, respe...

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Literature Corpus work: 9f1e0c33-bb21-57d3-b9d3-fd72037a0755
DOI: 10.1101/2024.10.30.620986

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