Article

CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITY

2023-01-02

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR/Cas is under development as a therapeutic tool for the cleavage, excision, and/or modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas from Streptococcus pyogenes (SpCas9) and Staphylococcus aureus (SaCas9), alternative CRISPR systems have been identified using metagenomic datasets from non-pathogenic microbes, including previously unknown class 2 syste...

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Literature Corpus work: 7ef2ab18-b004-5946-b8e2-34c0325e9ef1
DOI: 10.1101/2023.01.02.522476

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