Article
Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders.
The FEBS journal - 1 Sept 2026
Zambo Boglarka, Morlet Bastien, Negroni Luc, Mózner Orsolya, Sarkadi Balázs, Travé Gilles, Gogl Gergo
Abstract excerpt
GATA1 is a crucial transcription factor involved in hematopoiesis and mutations in this gene are linked to severe hematological disorders, including anemia, thrombocytopenia, Down syndrome-related transient abnormal myelopoiesis (DS-TAM), and myeloid leukemia of Down syndrome (ML-DS). Despite significant clinical interest in the molecular level characterization of GATA1 mutations, a comprehensive understanding of...
Read the complete abstract on PubMedTopics
- GATA1 Transcription Factor
- Humans
- DNA
- Protein Binding
- Mutation
- Promoter Regions, Genetic