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Article

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility.

Nature communications - 22 Feb 2018

Behera Vivek, Evans Perry, Face Carolyne J, Hamagami Nicole, Sankaranarayanan Laavanya, Keller Cheryl A, Giardine Belinda, Tan Kai, Hardison Ross C, Shi Junwei, Blobel Gerd A

Abstract excerpt

Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid cell lines. The impact of discriminatory single-nucleotide variants on TF ChIP signal enables...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29472540
DOI: 10.1038/s41467-018-03082-6
PMCID: PMC5823854

Genes

CTCF
GATA1
TAL1

Provenance

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