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Regulation of GATA1 levels in erythropoiesis

25 Nov 2019

Abstract excerpt

GATA1 is considered as the "master" transcription factor in erythropoiesis. It regulates at the transcriptional level all aspects of erythroid maturation and function, as revealed by gene knockout studies in mice and by genome-wide occupancies in erythroid cells. The GATA1 protein contains two zinc finger domains and an N-terminal transactivation domain. GATA1 translation results in the production of the...

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PMID: 31769197
DOI: 10.1002/iub.2192

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