Article
Somatic mutation as an explanation for epigenetic aging
2023-12-09
Abstract excerpt
DNA methylation marks have recently been used to build models known as “epigenetic clocks” which predict calendar age. As methylation of cytosine promotes C-to-T mutations, we hypothesized that the methylation changes observed with age should reflect the accrual of somatic mutations, and the two should yield analogous aging estimates. In analysis of multimodal data from 9,331 human individuals, we find that CpG mu...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- bca30964-5058-5e22-9f34-6a778c6693ba
- DOI
- 10.1101/2023.12.08.569638