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Article

DNA methylation and histone variants in aging and cancer.

International review of cell and molecular biology - 1 Jan 2021

Mangelinck Adèle, Mann Carl

Abstract excerpt

Aging-related diseases such as cancer can be traced to the accumulation of molecular disorder including increased DNA mutations and epigenetic drift. We provide a comprehensive review of recent results in mice and humans on modifications of DNA methylation and histone variants during aging and in cancer. Accumulated errors in DNA methylation maintenance lead to global decreases in DNA methylation with relaxed...

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PMID: 34507780
DOI: 10.1016/bs.ircmb.2021.06.002

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