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Article

Somatic mutation as an explanation for epigenetic aging.

Nature aging - 1 Apr 2025

Koch Zane, Li Adam, Evans Daniel S, Cummings Steven, Ideker Trey

Abstract excerpt

DNA methylation marks have recently been used to build models known as epigenetic clocks, which predict calendar age. As methylation of cytosine promotes C-to-T mutations, we hypothesized that the methylation changes observed with age should reflect the accrual of somatic mutations, and the two should yield analogous aging estimates. In an analysis of multimodal data from 9,331 human individuals, we found that...

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PMID: 39806003
DOI: 10.1038/s43587-024-00794-x
PMCID: PMC12204751

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