Somatic mutations and genome mosaicism in aging and disease.

Abstract excerpt

Age-related genome mosaicism is an inherent feature of multicellularity and genomic instability. It occurs because of DNA mutations, the accumulation of which leads to diverse genomic landscapes across different tissues. DNA mutations in the genome are consequences of DNA damage, changes in the chemical structure of DNA, such as strand breaks or loss of bases. DNA damage is very frequent and normally repaired...

Topics

• Humans
• Mosaicism
• Aging
• Mutation
• DNA Damage
• Animals
• Genomic Instability
• DNA Repair