Article
Genome-wide methylation profiles reveal quantitative views of human aging rates.
Molecular cell - 24 Jan 2013
Hannum Gregory, Guinney Justin, Zhao Ling, Zhang Li, Hughes Guy, Sadda SriniVas, Klotzle Brandy, Bibikova Marina, Fan Jian-Bing, Gao Yuan, Deconde Rob, Chen Menzies, Rajapakse Indika, Friend Stephen, Ideker Trey, Zhang Kang
Abstract excerpt
The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life. Although chronological age has been linked to changes in DNA methylation, the methylome has not yet been used to measure and compare human aging rates. Here, we build a quantitative model of aging using measurements at more than 450,000...
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