Article

Systems Analysis of de novo Mutations in Congenital Heart Diseases Identified a Molecular Network in Hypoplastic Left Heart Syndrome

2022-06-26

Abstract excerpt

Congenital heart diseases (CHD) are a class of birth defects affecting ∼1% of live births. These conditions are hallmarked by extreme genetic heterogeneity, and therefore, despite a strong genetic component, only a very handful of at-risk loci in CHD have been identified. We herein introduced systems analyses to uncover the hidden organization on biological networks of genomic mutations in CHD, and leveraged netwo...

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Literature Corpus work: 2b44104b-3561-5768-b98d-7751af760c49
DOI: 10.1101/2022.06.23.496464

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