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The Ca <sup>2+</sup> -gated Cl <sup>-</sup> channel TMEM16A amplifies capillary pericyte contraction reducing cerebral blood flow after ischemia

2022-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We show that a small rise in cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ) in pericytes activates chloride efflux through the Ca 2+ -gated anion channel TMEM16A, thus depolarizing the cell and opening voltage-gated ca...

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Literature Corpus work
bc99b126-9d7a-5601-93f9-9233f2a7bbfb
DOI
10.1101/2022.02.03.479031
Open publication

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