Article

Cardioprotection via brain-gut-heart signalling: GLP-1 activates KATP channels in coronary pericytes

2025-07-25

Abstract excerpt

<title>Abstract</title> <p> Failure to reperfuse the coronary microvasculature (“no-reflow”) affects up to 50% of patients after unblocking a coronary artery that was causing ischaemia and acute myocardial infarction. This “no-reflow” is associated with reduced left ventricular ejection fraction, increased infarct size, and death. We show that the incretin GLP-1 (glucagon-like peptide 1) can be used to protect t...

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Literature Corpus work: 8c719146-285d-5f11-8633-5127d050578a
DOI: 10.21203/rs.3.rs-7165083/v1

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