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TMEM16F scramblase regulates angiogenesis via endothelial intracellular signaling

28 Jun 2024

Abstract excerpt

TMEM16F (also known as ANO6), a Ca2+-activated lipid scramblase (CaPLSase) that dynamically disrupts lipid asymmetry, plays a crucial role in various physiological and pathological processes, such as blood coagulation, neurodegeneration, cell-cell fusion and viral infection. However, the mechanisms through which it regulates these processes remain largely elusive. Using endothelial cell-mediated angiogenesis as a...

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PMID: 38940198
DOI: 10.1242/jcs.261566

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