Article
Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations.
Circulation - 17 Jan 2012
Eikermann-Haerter Katharina, Lee Jeong Hyun, Yuzawa Izumi, Liu Christina H, Zhou Zhipeng, Shin Hwa Kyoung, Zheng Yi, Qin Tao, Kurth Tobias, Waeber Christian, Ferrari Michel D, van den Maagdenberg Arn M J M, Moskowitz Michael A, Ayata Cenk
Abstract excerpt
BACKGROUND: Migraine is an independent risk factor for stroke. Mechanisms underlying this association are unclear. Familial hemiplegic migraine (FHM), a migraine subtype that also carries an increased stroke risk, is a useful model for common migraine phenotypes because of shared aura and headache features, trigger factors, and underlying glutamatergic mechanisms. METHODS AND RESULTS: Here, we show that FHM type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.