Back to search

Article

Store-Operated Ca <sup>2+</sup> Channels Mediate Microdomain Ca <sup>2+</sup> Signals and Amplify Gq-Coupled Ca <sup>2+</sup> Elevations in Capillary Pericytes

2022-05-26

Abstract excerpt

Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties remain unexplored. Ca 2+ is a ubiquitous second messenger across cell-types, where it mediates diverse functions such as contractility and gene transcription. It is therefore important to understand the cellular mechanisms underlying Ca 2+ signalling in capillary peri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b0cbb286-d97f-5deb-9254-430493c4d46c
DOI
10.1101/2022.05.25.493438
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Store-Operated Ca <sup>2+</sup> Channels Mediate Microdomain Ca <sup>2+</sup> Signals and Amplify Gq-Coupled Ca <sup>2+</sup> Elevations in Capillary PericytesDOI 10.1101/2022.05.25.493438
The Ca <sup>2+</sup> -gated Cl <sup>-</sup> channel TMEM16A amplifies capillary pericyte contraction reducing cerebral blood flow after ischemiaSemantic proximity
Electromechanical Dynamics and Myogenic Responses in Cerebral Smooth Muscle Cells and Capillary PericytesSemantic proximity
ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors.Semantic proximity
Norepinephrine regulates Ca <sup>2+</sup> signals and fate of oligodendrocyte progenitor cells in the cortexSemantic proximity
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases.Semantic proximity
Pericytes mediate neurovascular remodeling in chronic arterial hypertensionSemantic proximity
<i>In situ</i> characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampusSemantic proximity
[Intracellular calcium: physiology and physiopathology].Semantic proximity
Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP <sub>2</sub> regeneration and activation of Kir2.1 channelsSemantic proximity
Distinct Ca <sup>2+</sup> signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationSemantic proximity
In situ characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampusSemantic proximity
Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentationSemantic proximity
Select a neighboring publication to make it the new centre.