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Article

ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2021

Hørlyck Sofie, Cai Changsi, Helms Hans Christian Cederberg, Lauritzen Martin, Brodin Birger

Abstract excerpt

Brain capillary pericytes have been suggested to play a role in the regulation of cerebral blood flow under physiological and pathophysiological conditions. ATP has been shown to cause constriction of capillaries under ischemic conditions and suggested to be involved in the "no-reflow" phenomenon. To investigate the effects of extracellular ATP on pericyte cell contraction, we studied purinergic receptor...

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Identifiers

PMID: 33306443
DOI: 10.1152/ajpheart.00560.2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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