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TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells

2024-05-23

Abstract excerpt

<h4>Rationale</h4> TRPV4 channels are critical regulators of blood vascular function and have been shown to be dysregulated in many disease conditions in association with inflammation and tissue fibrosis. These are key features in the pathophysiology of lymphatic system diseases, including lymphedema and lipedema; however, the role of TRPV4 channels in the lymphatic system remains largely unexplored. TRPV4 channe...

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Literature Corpus work: 6567a6f3-0df0-599f-a0f2-a23a07b49c3c
DOI: 10.1101/2024.05.21.595189

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