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Impaired intracellular Ca <sup>2+</sup> signaling contributes to age-related cerebral small vessel disease in <i>Col4a1</i> mutant mice

2022-08-26

Abstract excerpt

Humans and mice with mutations in COL4A1 and COL4A2 manifest hallmarks of cerebral small vessel disease (cSVD), but the pathogenic mechanisms are largely unknown. Mice with a missense mutation in Col4a1 at amino acid 1344 ( Col4a1 +/G1344D ) exhibited age-dependent intracerebral hemorrhage (ICH) and brain lesions. Here we report that this pathology was associated with the loss of myogenic vasoconstriction, an...

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Literature Corpus work
18e7cf1d-71b3-5d7c-be11-b7a8888ae2b8
DOI
10.1101/2022.08.24.505186
Open publication

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Impaired intracellular Ca <sup>2+</sup> signaling contributes to age-related cerebral small vessel disease in <i>Col4a1</i> mutant miceDOI 10.1101/2022.08.24.505186
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