Article

Towards whole-genome inference of polygenic scores with fast and memory-efficient algorithms

2025-01-22

Abstract excerpt

With improved Whole Genome Sequencing (WGS) and variant imputation techniques, modern Genome-wide Association Studies (GWASs) have enriched our understanding of the landscape of genetic associations for thousands of disease phenotypes. However, translating the marginal associations for millions of genetic variants to integrated polygenic risk scores (PRS) that capture their joint effects on the phenotype remains a...

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Literature Corpus work: bc7e60ba-42a1-5c28-b3fc-871978db7f19
DOI: 10.1101/2025.01.19.633789

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