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A flexible and parallelizable approach to genome-wide polygenic risk scores.

Genetic epidemiology - 1 Oct 2019

Newcombe Paul J, Nelson Christopher P, Samani Nilesh J, Dudbridge Frank

Abstract excerpt

The heritability of most complex traits is driven by variants throughout the genome. Consequently, polygenic risk scores, which combine information on multiple variants genome-wide, have demonstrated improved accuracy in genetic risk prediction. We present a new two-step approach to constructing genome-wide polygenic risk scores from meta-GWAS summary statistics. Local linkage disequilibrium (LD) is adjusted for...

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Area Under Curve
Coronary Artery Disease
Diabetes Mellitus, Type 1
Genome-Wide Association Study
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

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PMID: 31328830
DOI: 10.1002/gepi.22245
PMCID: PMC6764842

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