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Article

Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries.

Nature genetics - 1 May 2024

Zheng Zhili, Liu Shouye, Sidorenko Julia, Wang Ying, Lin Tian, Yengo Loic, Turley Patrick, Ani Alireza, Wang Rujia, Nolte Ilja M, Snieder Harold, Yang Jian, Wray Naomi R, Goddard Michael E, Visscher Peter M, Zeng Jian

Abstract excerpt

We develop a method, SBayesRC, that integrates genome-wide association study (GWAS) summary statistics with functional genomic annotations to improve polygenic prediction of complex traits. Our method is scalable to whole-genome variant analysis and refines signals from functional annotations by allowing them to affect both causal variant probability and causal effect distribution. We analyze 50 complex traits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38689000
DOI: 10.1038/s41588-024-01704-y
PMCID: PMC11096109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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