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Article

Fast and accurate Bayesian polygenic risk modeling with variational inference.

American journal of human genetics - 4 May 2023

Zabad Shadi, Gravel Simon, Li Yue

Abstract excerpt

The advent of large-scale genome-wide association studies (GWASs) has motivated the development of statistical methods for phenotype prediction with single-nucleotide polymorphism (SNP) array data. These polygenic risk score (PRS) methods use a multiple linear regression framework to infer joint effect sizes of all genetic variants on the trait. Among the subset of PRS methods that operate on GWAS summary...

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Identifiers

PMID: 37030289
DOI: 10.1016/j.ajhg.2023.03.009
PMCID: PMC10183379

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