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Article

Fine mapping and accurate prediction of complex traits using Bayesian Variable Selection models applied to biobank-size data.

European journal of human genetics : EJHG - 1 Mar 2023

de Los Campos Gustavo, Grueneberg Alexander, Funkhouser Scott, Pérez-Rodríguez Paulino, Samaddar Anirban

Abstract excerpt

Modern GWAS studies use an enormous sample size and ultra-high density SNP genotypes. These conditions reduce the mapping resolution of marginal association tests-the method most often used in GWAS. Multi-locus Bayesian Variable Selection (BVS) offers a one-stop solution for powerful and precise mapping of risk variants and polygenic risk score (PRS) prediction. We show (with an extensive simulation) that...

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PMID: 35853950
DOI: 10.1038/s41431-022-01135-5
PMCID: PMC9995454

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