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Article

SIngle cell level Genotyping Using scRna Data (SIGURD).

Briefings in bioinformatics - 23 Sept 2024

Grasshoff Martin, Kalmer Milena, Chatain Nicolas, Kricheldorf Kim, Maurer Angela, Weiskirchen Ralf, Koschmieder Steffen, Costa Ivan G

Abstract excerpt

MOTIVATION: By accounting for variants within measured transcripts, it is possible to evaluate the status of somatic variants using single-cell RNA-sequencing (scRNA-seq) and to characterize their clonality. However, the sparsity (very few reads per transcript) or bias in protocols (favoring 3' ends of the transcripts) makes the chance of capturing somatic variants very unlikely. This can be overcome by targeted...

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Computational Biology
Genotype
Genotyping Techniques
Mitochondria
Sequence Analysis, RNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Single-Cell Analysis

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PMID: 39559832
DOI: 10.1093/bib/bbae604
PMCID: PMC11574290

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