Article

Detecting Somatic Mutations in Rare Clones using Single Cell Multi-Omics

2025-10-31

Abstract excerpt

<h4>Background</h4> Somatic mutations are increasingly recognised as drivers of diseases beyond cancer, including autoimmune disorders. However, identifying rare, cell type-specific causal mutations remains challenging due to their low frequency within heterogeneous cell populations. Traditional bulk sequencing approaches lack the resolution to detect rare variants, underscoring the need for novel methods specifi...

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Literature Corpus work: cda3dac9-5130-521f-bfd5-8a89903aeee0
DOI: 10.1101/2025.10.30.685685

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