Article

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

2026-03-30

Abstract excerpt

Aging is associated with a progressive loss of skeletal muscle function, known as sarcopenia; however, the molecular mechanisms coordinating cellular stress responses and structural adaptations permissive of sarcopenia remain incompletely understood. In our previous studies, we found aging differentially impacted mitochondrial networks by muscle, suggesting unique stress thresholds and response activation. Here, w...

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Literature Corpus work: bc71d503-f436-5c0d-a033-ac1c03770a4f
DOI: 10.64898/2026.03.27.711928

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