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Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

2 May 2023

Abstract excerpt

Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse epigenetic aging in humans is unknown. Here, we performed a powerful meta-analysis of the methylome and transcriptome of an unprecedented number of human skeletal...

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PMID: 37128843
DOI: 10.1111/acel.13859

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